| ncRNA name | Sirt6 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human umbilical vein endothelial cells (HUVECs) |
| Methods | siRNA transfection, immunocytochemistry, SA-β-gal staining, Western blot, tube formation assay, RT-PCR |
| Expression pattern | associated |
| Functional description | The loss of Sirt6 was associated with an induction of a senescence phenotype in endothelial cells, including decreased cell growth, proliferation and angiogenic ability, and increased expression of senescence-associated β-galactosidase activity. Partial knockdown of Sirt6 expression by siRNA mimicked the effect of H2O2. |
| PubMed ID | 25162034 |
| Year | 2014 |
| Title | Oxidative stress induces endothelial cell senescence via downregulation of Sirt6. |
| Drug-related ncRNA | NO |
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